Frankly, there should be registry changes taking place on a computer if it is well protected, unless you are downloading unknown programs or doing a lot of P2P file sharing. But this is your own choice.
Only fix I see with HJT is this one
O2 - BHO: (no name) - {02478D38-C3F9-4EFB-9B51-7695ECA05670} - (no file)
Judy