Sorry maybe I wasn't clear, when it becomes unresponsive I ahve to reboot, which is why I asked should I start again, because all the ones I had closed would be back again, or if I should just carry on if none of them had made a difference the first time?
My Temp files are emptied about 2 times a week, (I don't usually use the computer everyday of the week) and Disk Cleanup was ran, the last time was at the beginning of the month, and I hadn't been on the computer again until I came on and this problem was there.