Riddle of the Day

[acoustikarl]

NEXT RIDDLE (a good one to ponder all weekend):


My first 2 letters refer to him;
Take my first 3 and it is she;
My first 4 letters talk of a great one;
Yet all my letters signify a great woman. What is this word?

So if the final word is 7 letters I believe I know the answer. I'll post Sunday night to give others a chance to figure it out.